Although, with some difficulty, I tried WSPR on 2m, I have never tried JT65 on 2m. As I recall, the main issue on 2m WSPR was drift and getting the rig on frequency. Frequency would be an issue still, but the 1 minute TX period is likely to make aircraft reflections more commonplace. Perhaps there are better modes for QRP DXing on 2m? I only have 2W and an omni antenna, so MS is out.
I don't even know the frequencies to use on 2m.