At the moment I am active on 10m WSPR and 6m JT65. I did a manual re-sync to internet time about 30 minutes ago "just in case". As yet, no Es on 6m but there has been Es on 10m WSPR with EA1FAQ (1249km) spotting my 500mW.
UPDATE 1540z: It helps to be on the right frequency! I have now gone QRT on 6m JT65 and 10m WSPR and fired up on 10m JT65. I noticed I was on 50.270 and not 50.276MHz. The dial lock was not on and the dial must have been knocked! I am now definitely on 28.076MHz JT65. So far, no spots.
UPDATE 1710z: Just G4CJC (73km) and OH1EEZ (1657km) spotting me so far. There is clearly some Es on 10m JT65.
UPDATE 1735z: Nothing from South America spotted on 10m JT65 here so far this evening.
UPDATE 1931z: I see that I have copied a South American in Brazil as well as a UK station (IO81) on 10m JT65, although neither station reported this to PSKreporter maps. LA7DFA (1312km) spotted me a little while ago.