Just been having an interesting debate on Facebook about someone requesting an eQSL for an exchange of WSPR reports. Some would argue that, simply exchanging reports via the WSPR database does not constitute a "real" QSO, so a QSL is not appropriate. Indeed, some would say the WSPR database report is itself a confirmation of the report (which it is) so what is the point of a QSL card? On HF contests it is VERY common for only one callsign to be heard in reports such as, "G3XBM 599233 TU" yet such exchanges are used for DXCC credits if a QSL card is sent following such a "contact".
Personally I would eQSL a full 2-way exchange of WSPR data if done within, say 10 minutes, on any given band and consider this valid. I will only do this in response to one received. Others may violently disagree!