Better equipped 6m stations are working some remarkable distances. There have been openings from Europe to South Africa and South America and reports of even further contacts. Although these could involve F2, the N-S QSOs are probably a combination of Es and TEP.
They don't call 6m (50MHz) the "magic band" without reason. With the right combination of propagation almost anything seems possible. Even with a very simple vertical antenna and 1W I have worked the USA on 6m QRP CW.
FT8 is an ideal mode as it is widely monitored on 50.313 MHz and works with fleeting signals much weaker than CW.
UPDATE 1948z: 6m opened to the USA this afternoon.