For almost my entire life, the gold at the end of the rainbow was nuclear fusion (not fission) with its promise of almost endless low cost energy with no pollution. At every point we seem to have hit hurdles and I cannot see it being reality in my lifetime. I hope in the end the technical issues can be overcome.
Things may have moved a step closer with a new research facility at Oxford funded by Jeoff Bazos. This is reported by the BBC to cost £400M.
See https://www.bbc.co.uk/news/science-environment-57512229 .